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Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants

28 Mar 2024

Abstract excerpt

The emergence of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) variants necessitated a rapid evaluation system for their pathogenesis. Lung epithelial cells are their entry points; however, in addition to their limited source, the culture of human alveolar epithelial cells is especially complicated. Induced pluripotent stem cells (iPSCs) are an alternative source of human primary stem cells. Here,...

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PMID: 38552631
DOI: 10.1016/j.stemcr.2024.02.011

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