Article

Human airway organoids as a versatile model to study BSL-4 virus replication and pathogenesis

2025-03-20

Abstract excerpt

Research with BSL-4 viruses such as Ebola, Marburg, and Nipah presents significant challenges due to their high virulence and the stringent containment measures required. A major limitation in studying viral pathogenesis and developing therapeutic strategies is the absence of suitable animal models that accurately replicate human disease. In this context, 3D cell culture systems offer significant advantages over t...

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Literature Corpus work: 0e3686ed-84cc-59b7-b339-065ef34c16b8
DOI: 10.1101/2025.03.20.644281

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