Article

Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites

2022-02-08

Abstract excerpt

During viral infection, competition ensues between viruses and their host cells to control the protein synthesis machinery. In response, certain host defense proteins globally limit mRNA translation. However, this is also detrimental for host protein synthesis. Here we describe an interferon-stimulated helicase, DDX60, that specifically inhibits translation from type II viral internal ribosome entry sites (IRESs)....

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Literature Corpus work: a33d5ab0-495d-5d2c-9cbd-e2f71a1c8c21
DOI: 10.1101/2022.02.08.479557

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