Article

Sex-Specific Effect of MTSS1 Downregulation on Dilated Cardiomyopathy

2024-03-01

Abstract excerpt

MTSS1 (metastasis suppressor 1) is an I-BAR protein that regulates cytoskeleton dynamics through interactions with actin, Rac, and actin-associated proteins. In a prior study, we identified genetic variants in a cardiac-specific enhancer upstream of MTSS1 that reduce human left ventricular (LV) MTSS1 expression and associate with protection against dilated cardiomyopathy (DCM). We sought to probe these effects fur...

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Literature Corpus work: a32060e0-7371-50a4-bb44-7552a2188b66
DOI: 10.1101/2024.02.28.24303451

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