Article

Reduced Expression of MTSS1 Increases Sarcomere Number and Improves Contractility in Select Forms of Monogenic DCM

2024-08-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The I-bar protein MTSS1 is a known modifier of heart failure and contractile phenotypes but its role in modulating contractile dysfunction in genetic forms of Mendelian dilated cardiomyopathy (DCM) is not known. <h4>Methods</h4> The potential role of cardiac MTSS1 in TTN DCM was explored using time-to-event models in longitudinal human datasets. Using induced siRNA and mutant...

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Literature Corpus work: 6f8e9ff8-7793-5491-91e1-faea563b0dc0
DOI: 10.1101/2024.08.14.24311020

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