Sex- and Exercise-Dependent Modulation of Hypertrophic Remodeling by the MCT1 rs1049434 Polymorphism.

doi:10.3390/genes17020188

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Sex- and Exercise-Dependent Modulation of Hypertrophic Remodeling by the MCT1 rs1049434 Polymorphism.

Genes - 2 Feb 2026

Fernández-Suárez Natalia, Viadero María Teresa, Amigo Teresa, Benitez-Muñoz José Antonio, Cupeiro Rocío, González-Lamuño Domingo

Abstract excerpt

BACKGROUND: The monocarboxylate transporter 1 (MCT1) plays a central role in myocardial lactate handling and metabolic adaptation. The functional rs1049434 polymorphism (T1470A; Asp490Glu) affects MCT1-mediated lactate transport and substrate utilization, but its clinical relevance in sarcomere-related hypertrophic cardiomyopathy (HCM) remains poorly defined. METHODS: We studied 56 carriers of pathogenic or...

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PMID: 41751573
DOI: 10.3390/genes17020188
PMCID: PMC12940516

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