Article

Profiling the Regulatory Landscape of Sialylation through miRNA Targeting of CMP- Sialic Acid Synthetase

2024-12-21

Abstract excerpt

Cell surface sialic acid is an important glycan modification that contributes to both normal and pathological physiology. The enzyme cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS) biosynthesizes the activated sugar donor cytidine monophosphate (CMP) sialic acid, which is required for all sialylation. CMAS levels impact sialylation with corresponding biological effects. The mechanisms that regulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a30ded32-813d-50d1-90b9-b2d0c0b2f58a
DOI: 10.1101/2024.12.18.629271

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Profiling the Regulatory Landscape of Sialylation through miRNA Targeting of CMP- Sialic Acid SynthetaseDOI 10.1101/2024.12.18.629271Read

Characterization of sialylation-related long noncoding RNAs to develop a novel signature for predicting prognosis, immune landscape, and chemotherapy response in colorectal cancerSemantic proximity Read

Sialylation is involved in cell fate decision during development, reprogramming and cancer progressionSemantic proximity Read

UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis.Semantic proximity Read

O-glycosylation contributes to mammalian glycoRNA biogenesisSemantic proximity Read

Structural basis for the delivery of activated sialic acid into Golgi for sialyationSemantic proximity Read

CRISPR activation screens map the genomic landscape of cancer glycome remodelingSemantic proximity Read

NHAPL analysis of glycoRNA reveals sialic acid-containing glycosylated mRNA 3′UTRs and enables sensitive SLE diagnosticsSemantic proximity Read

Blood<i>N</i>-glycomic signature of fibrosis in MASLD shows low levels of global α2,3-sialylationSemantic proximity Read

Genome-wide CRISPR screen reveals key role of sialic acids in PEDV and porcine coronavirus infectionsSemantic proximity Read

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and OpportunitiesSemantic proximity Read

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progressionSemantic proximity Read

Metabolic precision labeling enables selective probing of O-linked <i>N</i> -acetylgalactosamine glycosylationSemantic proximity Read