Back to search

Article

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

2022-04-28

Abstract excerpt

The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that the ST6GAL1 sialyltransferase, which adds α2,6-linked sialic acids to N -glycosylated proteins, is upregulated in patients with early-stage PDAC, and further increased in advanced disease. A tumor-promoting function for ST6GAL1 was elucidated using tumor x...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
54e29c28-0954-5ee6-b58d-86723f3c0a46
DOI
10.1101/2022.04.28.489561
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progressionDOI 10.1101/2022.04.28.489561
Integrated Systems Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveals a Tumor-Promoting Role for ST6GAL1Semantic proximity
Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1Semantic proximity
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasia.Semantic proximity
Global analysis of human glycosyltransferases reveals novel targets for pancreatic cancer pathogenesisSemantic proximity
LncRNA ST3Gal6‐AS1/ST3Gal6 axis mediates colorectal cancer progression by regulating α‐2,3 sialylation via PI3K/Akt signalingSemantic proximity
Nuclear Galectin-1 promotes KRAS -dependent activation of pancreatic cancer stellate cellsSemantic proximity
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuitsSemantic proximity
Quantitative Glycoproteomics Analysis Reveals Changes in N-Glycosylation Level Associated with Pancreatic Ductal AdenocarcinomaSemantic proximity
GATA6 in pancreatic cancer initiation and progressionSemantic proximity
Sialylation is involved in cell fate decision during development, reprogramming and cancer progressionSemantic proximity
Unraveling the glyco-immunity nexus in pancreatic cancerSemantic proximity
Mutant GNAS drives a pyloric metaplasia with tumor suppressive glycans in intraductal papillary mucinous neoplasiaSemantic proximity
Select a neighboring publication to make it the new centre.