Back to search

Article

Delineating the functional role of the <i>PPE50 (Rv3135) - PPE51 (Rv3136)</i> gene cluster in the pathophysiology of <i>Mycobacterium tuberculosis</i>

2023-03-30

Abstract excerpt

<h4>ABSTRACT</h4> The extraordinary success of Mycobacterium tuberculosis ( M. tb ) has been attributed to its ability to modulate host immune responses. The genome of M. tb encodes multiple immunomodulatory factors, including several proteins of the multigenic PE_PPE family, which comprise about 10% of its coding potential. The presence of these proteins in pathogenic mycobacteria strongly suggests that they...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5cc498c1-fdc3-536e-82ad-f8c3f9c03c3f
DOI
10.1101/2023.03.30.534876
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Delineating the functional role of the <i>PPE50 (Rv3135) - PPE51 (Rv3136)</i> gene cluster in the pathophysiology of <i>Mycobacterium tuberculosis</i>DOI 10.1101/2023.03.30.534876
The <i>PPE25 (Rv1787) - PE18 (Rv1788) - PPE26 (Rv1789)</i> gene cluster encodes an interacting protein pair and is involved in immune evasion by <i>Mycobacterium tuberculosis</i>Semantic proximity
The Mycobacterium tuberculosis PE Proteins Rv0285 and Rv1386 Modulate Innate Immunity and Mediate Bacillary Survival in MacrophagesSemantic proximity
Immunoregulatory functions and expression patterns of PE/PPE family members: Roles in pathogenicity and impact on anti‐tuberculosis vaccine and drug designSemantic proximity
<i>Mycobacterium tuberculosis</i> PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation?Semantic proximity
Mycobacterium tuberculosis PE_PGRS41 Enhances the Intracellular Survival of M. smegmatis within Macrophages Via Blocking Innate Immunity and Inhibition of Host DefenseSemantic proximity
The PE-PPE Family of Mycobacterium tuberculosis: Proteins in DisguiseSemantic proximity
Loss of the <i>PPE71-esxX-esxY-PPE38</i> locus drives adaptive transcriptional responses and hypervirulence of <i>Mycobacterium tuberculosis</i> Lineage 2Semantic proximity
Clusters of PE and PPE genes of <i>Mycobacterium tuberculosis</i> are organized in operons: Evidence that PE Rv2431c is co‐transcribed with PPE Rv2430c and their gene products interact with each otherSemantic proximity
Comparative genomic and proteomic analyses of PE/PPE multigene family of Mycobacterium tuberculosis H37Rv and H37Ra reveal novel and interesting differences with implications in virulenceSemantic proximity
PE11, a PE/PPE family protein of Mycobacterium tuberculosis is involved in cell wall remodeling and virulenceSemantic proximity
Role of the PE/PPE Family in Host–Pathogen Interactions and Prospects for Anti-Tuberculosis Vaccine and Diagnostic Tool DesignSemantic proximity
The Co-Operonic PE25/PPE41 Protein Complex of Mycobacterium tuberculosis Elicits Increased Humoral and Cell Mediated Immune ResponseSemantic proximity
Select a neighboring publication to make it the new centre.