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Article

Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.

BMC evolutionary biology - 21 Sept 2009

McEvoy Christopher R E, van Helden Paul D, Warren Robin M, Gey van Pittius Nicolaas C

Abstract excerpt

BACKGROUND: PPE38 (Rv2352c) is a member of the large PPE gene family of Mycobacterium tuberculosis and related mycobacteria. The function of PPE proteins is unknown but evidence suggests that many are cell-surface associated and recognised by the host immune system. Previous studies targeting other PPE gene members suggest that some display high levels of polymorphism and it is thought that this might represent a...

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PMID: 19769792
DOI: 10.1186/1471-2148-9-237
PMCID: PMC2758852

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NTM

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Evidence for a rapid rate of molecular evolution at the hypervariable and immunogenic Mycobacterium tuberculosis PPE38 gene region.PMID 19769792Read ↗

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