Article

Genome-wide association studies identify shared mechanisms between hypertension and type 2 diabetes independent of adiposity

2025-10-07

Abstract excerpt

<h4>Background</h4> Hypertension and type 2 diabetes (T2D) are two of the most frequently co-occurring long-term conditions, but their shared mechanisms are not fully understood, often being attributed to adiposity pathways. Here, we aimed to identify shared genetic mechanisms independent of adiposity. <h4>Methods</h4> We performed genome-wide association study meta-analyses of T2D and, separately, hypertension....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a2c85749-86d1-53df-a88d-3e9e0da23bd1
DOI: 10.1101/2025.10.03.25337275

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association studies identify shared mechanisms between hypertension and type 2 diabetes independent of adiposityDOI 10.1101/2025.10.03.25337275Read

Mechanistic Heterogeneity in Type 2 Diabetes and Hypertension Comorbidity Revealed with Partitioned Polygenic ScoresSemantic proximity Read

Genome-wide analysis reveals extensive genetic overlap between childhood phenotypes and later-life type 2 diabetes.Semantic proximity Read

Partitioned polygenic scores show mechanistic heterogeneity in type 2 diabetes and hypertension comorbidity.Semantic proximity Read

Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes.Semantic proximity Read

Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci.Semantic proximity Read

Defining type 2 diabetes polygenic risk scores through colocalization and network-based clustering of metabolic trait genetic associationsSemantic proximity Read

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read

Genetics identifies obesity as a shared risk factor for co-occurring multiple long-term conditionsSemantic proximity Read

Shared genetic risk factors and their implications for treatment of IPF and systemic hypertensionSemantic proximity Read

Investigating the shared genetic architecture between type 2 diabetes and strokeSemantic proximity Read

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.Semantic proximity Read

Exploring the shared genetic architecture of type 2 diabetes mellitus and bone mineral density.Semantic proximity Read