Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.

Journal of molecular and cellular cardiology - 1 May 2013

Paavola Jere, Schliffke Simon, Rossetti Sandro, Kuo Ivana Y-T, Yuan Shiaulou, Sun Zhaoxia, Harris Peter C, Torres Vicente E, Ehrlich Barbara E

Abstract excerpt

Mutations in PKD1 and PKD2, the genes encoding the proteins polycystin-1 (PC1) and polycystin-2 (PC2), cause autosomal dominant polycystic kidney disease (ADPKD). Although the leading cause of mortality in ADPKD is cardiovascular disease, the relationship between these conditions remains poorly understood. PC2 is an intracellular calcium channel expressed in renal epithelial cells and in cardiomyocytes, and is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Signaling
Share to Cardiomyopathy, Dilated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myocytes, Cardiac

Share to Podocytes

Share to Polycystic Kidney, Autosomal Dominant

Share to TRPP Cation Channels

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23376035
DOI: 10.1016/j.yjmcc.2013.01.015
PMCID: PMC3636149

Genes

PKD2
PKD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy.PMID 23376035Read ↗

Regulation of calcium signaling by polycystin-2Semantic proximity Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Polycystin 2: A calcium channel, channel partner, and regulator of calcium homeostasis in ADPKDSemantic proximity Read ↗

Congenital Heart Disease in Adults with Autosomal Dominant Polycystic Kidney Disease.Semantic proximity Read ↗

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeastSemantic proximity Read ↗

Polycystin-2 (PC2): structural insights and its role in disease pathogenesis.Semantic proximity Read ↗

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein.Semantic proximity Read ↗

Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells.Semantic proximity Read ↗

Cardiac Localized Polycystin-2 plays a Functional Role in Natriuretic Peptide Production and its Absence Contributes to HypertensionSemantic proximity Read ↗

Polycystin-2 is cardioprotective against myocardial infarction by regulating the calcium-mediated ER stress responseSemantic proximity Read ↗

Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.Semantic proximity Read ↗

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.