Article

A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube Defects

2023-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Neural tube defects (NTDs) including anencephaly and spina bifida are common major malformations of fetal development resulting from incomplete closure of the neural tube. These conditions lead to either universal death (anencephaly) or life-long severe complications (spina bifida). Despite hundreds of genetic mouse models having neural tube defect phenotypes, the genetics of human NTDs are poor...

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Literature Corpus work: d36fe544-f425-5398-8b4a-e26f6a198890
DOI: 10.1101/2023.04.11.536245

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