Article

All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer

2024-10-23

Abstract excerpt

As a double-stranded RNA–editing enzyme and an interferon-stimulated gene, double-stranded RNA-specific adenosine deaminase (ADAR1) suppresses interferon signaling and contributes to immunotherapy resistance. Suppression of ADAR1 overcomes immunotherapy resistance in preclinical models, but has not yet been translated to clinical settings. By conducting a screening of a subset of the FDA-approved drugs, we found t...

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Literature Corpus work: a2b61aa2-1f6e-5adc-badc-8bb7c5a184ab
DOI: 10.1101/2024.10.20.619300

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