Article

ADAR1 editing dependency in triple-negative breast cancer

2020-02-02

Abstract excerpt

<h4>Summary</h4> Triple-negative breast cancer (TNBC) is the deadliest form of breast cancer. Unlike other types of breast cancer that can be effectively treated by targeted therapies, no such targeted therapy exists for all TNBC patients. The ADAR1 enzyme carries out A-to-I editing of RNA to prevent sensing of cellular double-stranded RNAs (dsRNA). ADAR1 is highly expressed in breast cancer including TNBC. Here,...

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Literature Corpus work: 95257e81-8f25-5874-8a40-c0d4a8f14ac3
DOI: 10.1101/2020.01.31.928911

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