Back to search

Article

Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo

2021-02-19

Abstract excerpt

Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in multiple immune cell populations including Th17 cells, where its primary function is regulation of immune responses to bacteria and fungi through IL-17A production. Howeve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d2d96200-4945-5d7b-ac7d-4181e903a906
DOI
10.1101/2021.02.19.431952
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivoDOI 10.1101/2021.02.19.431952
Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivoSemantic proximity
Retinoic acid receptor-related orphan receptor gamma-t (RORγt) inhibitors in clinical development for the treatment of autoimmune diseases: a patent review (2016-present)Semantic proximity
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper CellsSemantic proximity
RORγt and RORα signature genes in human Th17 cellsSemantic proximity
Transcription Factor Retinoid-Related Orphan Receptor γt: A Promising Target for the Treatment of PsoriasisSemantic proximity
Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)Semantic proximity
Genetic and pharmacological inhibition of the nuclear receptor RORα regulates TH17 driven inflammatory disordersSemantic proximity
CD8+ T Cells That Coexpress RORγt and T-bet Are Functionally Impaired and Expand in Patients with Distal Bile Duct Cancer.Semantic proximity
A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development.Semantic proximity
Ternary complex of human RORγ ligand-binding domain, inverse agonist and SMRT peptide shows a unique mechanism of corepressor recruitment.Semantic proximity
TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populationsSemantic proximity
All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancerSemantic proximity
Select a neighboring publication to make it the new centre.