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A Tale of Two Checkpoints: ATR Inhibition and PD-(L)1 Blockade

13 Oct 2021

Abstract excerpt

Innate immunity and the DNA damage response (DDR) pathway are inextricably linked. Within the DDR, ataxia telangiectasia and Rad3-related (ATR) is a key kinase responsible for sensing replication stress and facilitating DNA repair through checkpoint activation, cell cycle arrest, and promotion of fork recovery. Recent studies have shed light on the immunomodulatory role of the ATR-CHK1 pathway in the tumor...

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PMID: 34644155
DOI: 10.1146/annurev-med-042320-025136

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