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Article

Adar1 deletion causes degeneration of the exocrine pancreas via Mavs-dependent interferon signaling.

Development (Cambridge, England) - 15 Jan 2023

Rupani Dhwani N, Thege Fredrik I, Chandra Vidhi, Rajaei Hajar, Cowan Robert W, Wörmann Sonja M, Le Roux Olivereen, Malaney Prerna, Manning Sara L, Hashem Jack, Bailey-Lundberg Jennifer, Rhim Andrew D, McAllister Florencia

Abstract excerpt

Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional RNA processing, making ADAR1 a crucial regulator of gene expression. Consequently, Adar1 has been implicated in organogenesis. To determine the role of Adar1 in pancreatic development and homeostasis, we conditionally deleted Adar1 from the murine pancreas...

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Identifiers

PMID: 36458554
DOI: 10.1242/dev.201097
PMCID: PMC10110501

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