Article

Tenascin-C in the early lung cancer tumor microenvironment promotes progression through integrin αvβ1 and FAK

2024-09-21

Abstract excerpt

Pre-cancerous lung lesions are commonly initiated by activating mutations in the RAS pathway, but do not transition to lung adenocarcinomas (LUAD) without additional oncogenic signals. Here, we show that expression of the extracellular matrix protein Tenascin-C (TNC) is increased in and promotes the earliest stages of LUAD development in oncogenic KRAS-driven lung cancer mouse models and in human LUAD. TNC is init...

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Literature Corpus work: a2b17022-ebf1-53f9-aad1-b7c098762433
DOI: 10.1101/2024.09.17.613509

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