Article
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium.
The Journal of clinical investigation - 1 May 2011
Pacheco-Pinedo Eugenia C, Durham Amy C, Stewart Kathleen M, Goss Ashley M, Lu Min Min, Demayo Francesco J, Morrisey Edward E
Abstract excerpt
Although mutations in Kras are present in 21% of lung tumors, there is a high level of heterogeneity in phenotype and outcome among patients with lung cancer bearing similar mutations, suggesting that other pathways are important. Wnt/β-catenin signaling is a known oncogenic pathway that plays a well-defined role in colon and skin cancer; however, its role in lung cancer is unclear. We have shown here that...
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