Article

Dysregulation of Hepatitis B Virus Nucleocapsid Assembly with RNA-directed Small Ligands

2021-08-10

Abstract excerpt

RNA sequences/motifs dispersed across the pre-genomic copy of the Hepatitis B Virus genome regulate formation of nucleocapsids in vitro in an epsilon/polymerase independent fashion. These multiple RNA Packaging Signals (PSs) form stem-loops presenting in each loop a core protein recognition motif, -RGAG-. Small, drug-like molecules binding these motifs were identified by screening an immobilized library with a fl...

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Literature Corpus work: a2a910f1-7232-587b-b079-9297031d283d
DOI: 10.1101/2021.08.10.455820

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