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Article

Genomic RNA folding mediates assembly of human parechovirus

10 Feb 2017

Abstract excerpt

Assembly of the major viral pathogens of the Picornaviridae family is poorly understood. Human parechovirus 1 is an example of such viruses that contains 60 short regions of ordered RNA density making identical contacts with the protein shell. We show here via a combination of RNA-based systematic evolution of ligands by exponential enrichment, bioinformatics analysis and reverse genetics that these RNA segments...

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PMID: 28232749
DOI: 10.1038/s41467-016-0011-z

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