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Article

Functionally conserved architecture of hepatitis C virus RNA genomes.

Proceedings of the National Academy of Sciences of the United States of America - 24 Mar 2015

Mauger David M, Golden Michael, Yamane Daisuke, Williford Sara, Lemon Stanley M, Martin Darren P, Weeks Kevin M

Abstract excerpt

Hepatitis C virus (HCV) infects over 170 million people worldwide and is a leading cause of liver disease and cancer. The virus has a 9,650-nt, single-stranded, messenger-sense RNA genome that is infectious as an independent entity. The RNA genome has evolved in response to complex selection pressures, including the need to maintain structures that facilitate replication and to avoid clearance by cell-intrinsic...

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Identifiers

PMID: 25775547
DOI: 10.1073/pnas.1416266112
PMCID: PMC4378395

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Source receipt: pubmed, retrieved 7 Sept 2026.

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