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Article

Identification of novel RNA secondary structures within the hepatitis C virus genome reveals a cooperative involvement in genome packaging.

Scientific reports - 14 Mar 2016

Stewart H, Bingham R J, White S J, Dykeman E C, Zothner C, Tuplin A K, Stockley P G, Twarock R, Harris M

Abstract excerpt

The specific packaging of the hepatitis C virus (HCV) genome is hypothesised to be driven by Core-RNA interactions. To identify the regions of the viral genome involved in this process, we used SELEX (systematic evolution of ligands by exponential enrichment) to identify RNA aptamers which bind specifically to Core in vitro. Comparison of these aptamers to multiple HCV genomes revealed the presence of a conserved...

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Share to Aptamers, Nucleotide
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26972799
DOI: 10.1038/srep22952
PMCID: PMC4789732

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