Article

Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR

2024-09-07

Abstract excerpt

Human Immunodeficiency Virus (HIV) persists as a leading global health issue. A significant gap in knowledge exists in our understanding of long-range interactions within the HIV-1 RNA genome. To bridge this gap, we introduce HiCapR, incorporating a psoralen crosslinking RNA proximity ligation and post-library hybridization for capturing HIV RNA-RNA interactions. Leveraging HiCapR, we confirm the presence of stem...

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Literature Corpus work: 7830444f-6e9f-506f-aa6c-2a616393b470
DOI: 10.1101/2024.09.03.610837

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