Article

Modulation of immunopathogenic matrix metalloproteinases in pulmonary tuberculosis by T helper-17 cytokines & the PI 3-kinase pathway

2012-01-01

Abstract excerpt

Mycobacterium tuberculosis (Mtb) kills 1.7 million people annually. The Th1 paradigm does not explain TB-driven cavitation. Current treatment is lengthy with many adverse effects. The IL-23/Th17 axis plays a critical role in early Mtb containment. Respiratory stromal cells are important first-line defence and secrete MMPs. Regulation of Matrix metalloproteinases (MMPs), which are substrate-specific proteases causi...

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Literature Corpus work: a29576f0-3afc-57bc-a99b-65f3a237c2ef
DOI: 10.25560/9605

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