Article
Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD.
Respiratory research - 23 Aug 2011
Heijink Irene H, Brandenburg Simone M, Noordhoek Jacobien A, Slebos Dirk-Jan, Postma Dirkje S, van Oosterhout Antoon J
Abstract excerpt
BACKGROUND: Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribute to increased pro-inflammatory epithelial responses with respect to the release of IL-8 and TGF-α, cytokines implicated in COPD pathogenesis. METHODS: We studied the effects...
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