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Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology

1 Jun 2017

Abstract excerpt

Tuberculosis remains a global pandemic and drives lung matrix destruction to transmit. Whilst pathways driving inflammatory responses in macrophages have been relatively well described, negative regulatory pathways are less well defined. We hypothesised that Mycobacterium tuberculosis (Mtb) specifically targets negative regulatory pathways to augment immunopathology. Inhibition of signalling through the...

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PMID: 28570642
DOI: 10.1371/journal.ppat.1006367

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