Back to search

Article

Neutrophils and the regulation of matrix metalloproteinases in tuberculosis

2013-01-01

Abstract excerpt

Tuberculosis (TB) continues to kill globally and this is compounded by increasing drug-resistance. Neutrophil influx and tissue destruction are hallmarks of TB and this is detrimental to the host. A matrix degrading phenotype causes tissue damage in TB whereby the activity of matrix metalloproteinases (MMPs) is unopposed by their specific tissue inhibitors (TIMPs). The hypothesis is that neutrophils have a key rol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d29df0a8-72c6-5c79-8001-7d795f81a118
DOI
10.25560/39360
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Neutrophils and the regulation of matrix metalloproteinases in tuberculosisDOI 10.25560/39360
The role of matrix metalloproteinases in leukocyte migration and collagen degradation in tuberculosisSemantic proximity
Matrix metalloproteinases in tuberculosisSemantic proximity
Regulation of inflammation by platelets in tuberculosisSemantic proximity
Tissue specificity of MMP gene expression and secretion in tuberculosisSemantic proximity
The role of matrix metalloproteinases in the immunopathology of cerebral tuberculosisSemantic proximity
Modulation of immunopathogenic matrix metalloproteinases in pulmonary tuberculosis by T helper-17 cytokines & the PI 3-kinase pathwaySemantic proximity
Neutrophil-primed immunopathology in poorly-controlled diabetes worsens matrix destruction in pulmonary tuberculosisSemantic proximity
MMPs and NETs are detrimental in human CNS-tuberculosis and MMP inhibition in a mouse model improves survivalSemantic proximity
Neutrophils in Tuberculosis: Cell Biology, Cellular Networking and Multitasking in Host DefenseSemantic proximity
Matrix Metalloproteinases and Their Inhibitors in Chronic Obstructive Pulmonary Disease.Semantic proximity
Investigating neutrophil cell death in TB pathogenesisSemantic proximity
Neutrophil subsets play dual roles in tuberculosis by producing inflammasome dependent-IL-1β or suppressing T-cells via PD-L1Semantic proximity
Select a neighboring publication to make it the new centre.