Article

The role of matrix metalloproteinases in the immunopathology of cerebral tuberculosis

2009-01-01

Abstract excerpt

Introduction: Central nervous system tuberculosis (CNS TB) has a high mortality. Microglial derived matrix metalloproteinases (MMPs) are implicated in the intense inflammatory response to Mycobacterium tuberculosis (M.tb) as the blood brain barrier is rich in MMP substrates. Methods: In a cellular model of CNS TB human microglial cells were stimulated with M.tb and conditioned media from M.tb infected human monocy...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e58236a5-65a9-5ef6-9b0a-01b0aec33ae8
DOI: 10.25560/4640

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The role of matrix metalloproteinases in the immunopathology of cerebral tuberculosisDOI 10.25560/4640Read

Tissue specificity of MMP gene expression and secretion in tuberculosisSemantic proximity Read

Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo.Semantic proximity Read

The role of matrix metalloproteinases in leukocyte migration and collagen degradation in tuberculosisSemantic proximity Read

Modulation of immunopathogenic matrix metalloproteinases in pulmonary tuberculosis by T helper-17 cytokines & the PI 3-kinase pathwaySemantic proximity Read

MMPs and NETs are detrimental in human CNS-tuberculosis and MMP inhibition in a mouse model improves survivalSemantic proximity Read

Neutrophils and the regulation of matrix metalloproteinases in tuberculosisSemantic proximity Read

Matrix metalloproteinases in tuberculosisSemantic proximity Read

Regulation of inflammation by platelets in tuberculosisSemantic proximity Read

Matrix metalloproteinases, their production by monocytes and macrophages and their potential role in HIV-related diseasesSemantic proximity Read

Mycobacterium tuberculosis Upregulates TNF-α Expression via TLR2/ERK Signaling and Induces MMP-1 and MMP-9 Production in Human Pleural Mesothelial CellsSemantic proximity Read

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosisSemantic proximity Read

Hypoxia and the mechanisms regulating inflammatory tissue destruction in tuberculosisSemantic proximity Read