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Article

An integrated analysis of human myeloid cells identifies gaps in in vitro models of in vivo biology.

Stem cell reports - 8 Jun 2021

Rajab Nadia, Angel Paul W, Deng Yidi, Gu Jennifer, Jameson Vanta, Kurowska-Stolarska Mariola, Milling Simon, Pacheco Chris M, Rutar Matt, Laslett Andrew L, Lê Cao Kim-Anh, Choi Jarny, Wells Christine A

Abstract excerpt

The Stemformatics myeloid atlas is an integrated transcriptome atlas of human macrophages and dendritic cells that systematically compares freshly isolated tissue-resident, cultured, and pluripotent stem cell-derived myeloid cells. Three classes of tissue-resident macrophage were identified: Kupffer cells and microglia; monocyte-associated; and tumor-associated macrophages. Culture had a major impact on all...

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Identifiers

PMID: 33989517
DOI: 10.1016/j.stemcr.2021.04.010
PMCID: PMC8190595

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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