Article

UHRF1 upregulation mediates exosome release and tumor progression in osteosarcoma

2020-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Loss of function mutations at the retinoblastoma ( RB1 ) gene are associated with increased mortality, metastasis and poor therapeutic outcome in several cancers, including osteosarcoma (OS). However, the mechanism(s) through which RB1 loss worsens clinical outcome remain to be elucidated. Ubiquitin-like with PHD and Ring Finger domains 1 (UHRF1) has been identified as a critical downstream ef...

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Literature Corpus work: 6a6d5ddc-7a4c-518d-ac79-29cbb7dec197
DOI: 10.1101/2020.05.24.113647

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