Article

Development of D-box peptides to inhibit the Anaphase Promoting Complex/Cyclosome

2024-04-30

Abstract excerpt

E3 ubiquitin ligases engage their substrates via ‘degrons’ - short linear motifs typically located within intrinsically disordered regions of substrates. As these enzymes are large, multi-subunit complexes that generally lack natural small-molecule ligands and are hard to drug via conventional means, alternative strategies are needed to target them in diseases, and peptide-based inhibitors derived from degrons rep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a270ee80-267b-5416-b39a-4ff8db8b227d
DOI: 10.1101/2024.04.30.590460

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Development of D-box peptides to inhibit the Anaphase Promoting Complex/CyclosomeDOI 10.1101/2024.04.30.590460Read

Degradation of intrinsically disordered proteins using proteolysis targeting nanobody conjugateSemantic proximity Read

Heterobifunctional proteomimetic polymers for targeted protein degradationSemantic proximity Read

Precision medicine by designer interference peptides: applications in oncology and molecular therapeuticsSemantic proximity Read

bioPROTACs as versatile modulators of intracellular therapeutic targets: Application to proliferating cell nuclear antigen (PCNA)Semantic proximity Read

Enhancing c-MYC degradation via 20S proteasome activation induces <i>in vivo</i> anti-tumor efficacySemantic proximity Read

Placing a disrupted degradation motif at the C terminus of proteasome substrates attenuates degradation without impairing ubiquitylation.Semantic proximity Read

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).Semantic proximity Read

Designed peptide binders and nanobodies as PROTAC starting points for targeted degradation of PCNA and BCL6Semantic proximity Read

Design of a Cereblon construct for crystallographic and biophysical studies of protein degradersSemantic proximity Read

Tailoring Peptidomimetics for Targeting Protein–Protein InteractionsSemantic proximity Read

Identification of KLHDC2 as an efficient proximity-induced degrader of K-RAS, STK33, β-catenin, and FoxP3Semantic proximity Read

The contribution of native protein complexes to targeted protein degradationSemantic proximity Read