Degradation of intrinsically disordered proteins using proteolysis targeting nanobody conjugate

Abstract excerpt

Intrinsically disordered proteins (IDPs) play crucial roles in diverse cellular processes and are implicated in numerous diseases. However, due to the inherently unstructured nature, it is challenging to modulate their function using small molecule degraders or inhibitors. To address this, we introduced proteolysis targeting nanobody conjugate (PROTNC) composed of a nanobody that binds to an IDP, an E3 ligase liga...

Topics

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• Acrylamides
• Agammaglobulinaemia Tyrosine Kinase
• Fluorescent Dyes
• Half-Life
• Intracellular Space
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

b64537aa-3684-554c-b224-0117b79f3a8e

DOI

10.1101/2024.11.27.622182