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Article

The contribution of native protein complexes to targeted protein degradation

2025-06-17

Abstract excerpt

Targeted protein degradation (TPD) destroys proteins of interest (POIs) by hijacking the cellular proteolytic machinery. Most proteins in cells exist and function as part of multi-protein or macromolecular complexes, thereby allowing a single protein to control multiple biological processes. Therefore, when a small molecule degrader induces proximity between an E3 ligase and the POI, the macromolecular context of...

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Identifiers and source

Literature Corpus work
4fb3278a-22c9-50d8-836c-d8f6867f87ee
DOI
10.1101/2025.06.17.660125
Open publication

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The contribution of native protein complexes to targeted protein degradationDOI 10.1101/2025.06.17.660125
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