Article

Enhancing c-MYC degradation via 20S proteasome activation induces <i>in vivo</i> anti-tumor efficacy

2020-08-24

Abstract excerpt

<h4>SUMMARY</h4> Enhancing proteasome activity is a potential new therapeutic strategy to prevent the accumulation of aberrant high levels of protein that drive the pathogenesis of many diseases. Herein, we examine the use of small molecules to activate the 20S proteasome to reduce aberrant signaling by the undruggable oncoprotein c-MYC, to treat c-MYC driven oncogenesis. Overexpression of c-MYC is found in more...

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Literature Corpus work: 0d2bf7cc-d24b-56f7-b1ce-4f1bb5a8ec61
DOI: 10.1101/2020.08.24.265470

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