Article

IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data

2022-12-27

Abstract excerpt

In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning them to specific germline alleles, and inferring individual genotypes are challenging when the repertoire is highly mutated, or sequence reads do not cover the whole...

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Literature Corpus work: a266d51c-0190-52ab-94f3-d8b93fae5bf7
DOI: 10.1101/2022.12.26.521922

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