Article
IGHV allele similarity clustering improves genotype inference from adaptive immune receptor repertoire sequencing data.
Nucleic acids research - 8 Sept 2023
Peres Ayelet, Lees William D, Rodriguez Oscar L, Lee Noah Y, Polak Pazit, Hope Ronen, Kedmi Meirav, Collins Andrew M, Ohlin Mats, Kleinstein Steven H, Watson Corey T, Yaari Gur
Abstract excerpt
In adaptive immune receptor repertoire analysis, determining the germline variable (V) allele associated with each T- and B-cell receptor sequence is a crucial step. This process is highly impacted by allele annotations. Aligning sequences, assigning them to specific germline alleles, and inferring individual genotypes are challenging when the repertoire is highly mutated, or sequence reads do not cover the whole...
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