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Oral immunization with a probiotic cholera vaccine induces broad protective immunity against <i>Vibrio cholerae</i> colonization and disease in mice

2019-02-20

Abstract excerpt

Oral cholera vaccines (OCVs) are being increasingly employed, but current killed formulations generally require multiple doses and lack efficacy in young children. We recently developed a new live-attenuated OCV candidate (HaitiV) derived from a Vibrio cholerae strain isolated during the 2010 Haiti cholera epidemic. HaitiV exhibited an unexpected probiotic-like activity in infant rabbits, preventing intestinal co...

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Identifiers and source

Literature Corpus work
a262881b-e256-548d-9244-4207b81b945b
DOI
10.1101/554303
Open publication

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Oral immunization with a probiotic cholera vaccine induces broad protective immunity against <i>Vibrio cholerae</i> colonization and disease in miceDOI 10.1101/554303
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