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Non-toxigenic <i>Vibrio cholerae</i> challenge strains for evaluating vaccine efficacy and inferring mechanisms of protection

2021-12-18

Abstract excerpt

Human challenge studies are instrumental for testing cholera vaccines, but these studies use outdated strains and require inpatient facilities. Here, we created next-generation isogenic Ogawa and Inaba V. cholerae challenge strains (ZChol strains) derived from a contemporary Zambian clinical isolate representative of current dominant pandemic V. cholerae . To minimize the risk of severe diarrhea these strains we...

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Literature Corpus work
d313852f-0462-5661-a42a-d3e00aff4880
DOI
10.1101/2021.12.17.473008
Open publication

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Non-toxigenic <i>Vibrio cholerae</i> challenge strains for evaluating vaccine efficacy and inferring mechanisms of protectionDOI 10.1101/2021.12.17.473008
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