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Article

A live vaccine rapidly protects against cholera in an infant rabbit model

13 Jun 2018

Abstract excerpt

reduced intestinal colonization by the wild-type strain, slowed disease progression, and reduced mortality in an infant rabbit model of cholera. HaitiV-mediated protection required viable vaccine, and rapid protection kinetics are not consistent with development of adaptive immunity. These features suggest that HaitiV mediates probiotic-like protection from cholera, a mechanism that is not known to be elicited by...

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PMID: 29899024
DOI: 10.1126/scitranslmed.aap8423

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