Article

Safety and immunogenicity of PanChol, a single-dose live-attenuated oral cholera vaccine: results from a phase 1a, double-blind, randomized, placebo-controlled trial

2025-09-14

Abstract excerpt

<h4>Background</h4> Current whole-cell killed oral cholera vaccines have utility but require multiple doses and have limited efficacy in young children. PanChol is a single-dose live-attenuated cholera vaccine derived from the current seventh pandemic Vibrio cholerae O1 strain. It co-expresses Inaba and Ogawa antigens, over-expresses the non-toxic cholera toxin B subunit, and is designed to minimize reactogenicit...

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Literature Corpus work: 95ea23c5-c7fb-50f6-bda6-b4ca0bf5d0b3
DOI: 10.1101/2025.09.12.25335655

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