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Article

Reproductive and metabolic phenotype of a mouse model of PCOS.

Endocrinology - 1 Jun 2012

van Houten E Leonie A F, Kramer Piet, McLuskey Anke, Karels Bas, Themmen Axel P N, Visser Jenny A

Abstract excerpt

Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women in their reproductive age, is characterized by both reproductive and metabolic features. Recent studies in human, nonhuman primates, and sheep suggest that hyperandrogenism plays an important role in the development of PCOS. We investigated whether chronic dihydrotestosterone (DHT) exposure in mice reproduces both features of PCOS. Such...

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PMID: 22334715
DOI: 10.1210/en.2011-1754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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