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Evolution of HER2-positive mammary carcinoma: HER2 loss reveals claudin-low traits in cancer progression

13 Nov 2021

Abstract excerpt

Abstract HER2-positive breast cancers may lose HER2 expression in recurrences and metastases. In this work, we studied cell lines derived from two transgenic mammary tumors driven by human HER2 that showed different dynamics of HER2 status. MamBo89HER2stable cell line displayed high and stable HER2 expression, which was maintained upon in vivo passages, whereas MamBo43HER2labile cell line gave rise to...

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PMID: 34775465
DOI: 10.1038/s41389-021-00360-9

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