Article
Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.
2023-11-21
Abstract excerpt
New genes (or young genes) are structural novelties pivotal in mammalian evolution. Their phenotypic impact on humans, however, remains elusive due to the technical and ethical complexities in functional studies. Through combining gene age dating with Mendelian disease phenotyping, our research reveals that new genes associated with disease phenotypes steadily integrate into the human genome at a rate of ~ 0.07% e...
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Identifiers and source
- Literature Corpus work
- a24039c0-d7b2-53ab-bc19-680039a1e132
- DOI
- 10.21203/rs.3.rs-3632644/v1