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Article

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.

Genome research - 18 Mar 2025

Chen Jian-Hai, Landback Patrick, Arsala Deanna, Guzzetta Alexander, Xia Shengqian, Atlas Jared, Sosa Dylan, Zhang Yong E, Cheng Jingqiu, Shen Bairong, Long Manyuan

Abstract excerpt

New genes (or young genes) are genetic novelties pivotal in mammalian evolution. However, their phenotypic impacts and evolutionary patterns over time remain elusive in humans owing to the technical and ethical complexities of functional studies. Integrating gene age dating with Mendelian disease phenotyping, we reveal a gradual rise in disease gene proportion as gene age increases. Logistic regression modeling...

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PMID: 39952680
DOI: 10.1101/gr.279498.124
PMCID: PMC11960464

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