Article
Gene age predicts the strength of purifying selection acting on gene expression variation in humans.
American journal of human genetics - 4 Dec 2014
Popadin Konstantin Y, Gutierrez-Arcelus Maria, Lappalainen Tuuli, Buil Alfonso, Steinberg Julia, Nikolaev Sergey I, Lukowski Samuel W, Bazykin Georgii A, Seplyarskiy Vladimir B, Ioannidis Panagiotis, Zdobnov Evgeny M, Dermitzakis Emmanouil T, Antonarakis Stylianos E
Abstract excerpt
Gene expression levels can be subject to selection. We hypothesized that the age of gene origin is associated with expression constraints, given that it affects the level of gene integration into the functional cellular environment. By studying the genetic variation affecting gene expression levels (cis expression quantitative trait loci [cis-eQTLs]) and protein levels (cis protein QTLs [cis-pQTLs]), we...
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