Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.

Aging - 29 Mar 2018

Kulminski Alexander M, Huang Jian, Loika Yury, Arbeev Konstantin G, Bagley Olivia, Yashkin Arseniy, Duan Matt, Culminskaya Irina

Abstract excerpt

A conceptual difficulty in genetics of age-related phenotypes that make individuals vulnerable to disease in post-reproductive life is genetic heterogeneity attributed to an undefined role of evolution in establishing their molecular mechanisms. Here, we performed univariate and pleiotropic genome-wide meta-analyses of 20 age-related phenotypes leveraging longitudinal information in a sample of 33,431 individuals...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genome-Wide Association Study

Share to Genotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 29615537
DOI: 10.18632/aging.101407
PMCID: PMC5892700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.PMID 29615537Read ↗

Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related DiseasesSemantic proximity Read ↗

The impact of non-additive genetic associations on age-related complex diseasesSemantic proximity Read ↗

Centenarians as extreme phenotypes: An ecological perspective to get insight into the relationship between the genetics of longevity and age-associated diseases.Semantic proximity Read ↗

Evidence for the role of selection for reproductively advantageous alleles in human agingSemantic proximity Read ↗

Unraveling Genetic Origin of Aging-Related Traits: Evolving ConceptsSemantic proximity Read ↗

Genetic association data are broadly consistent with stabilizing selection shaping human common diseases and traitsSemantic proximity Read ↗

Common genetic associations between age-related diseasesSemantic proximity Read ↗

Evidence for the role of selection for reproductively advantageous alleles in human aging.Semantic proximity Read ↗

Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.Semantic proximity Read ↗

The impact of non-additive genetic associations on age-related complex diseases.Semantic proximity Read ↗

Evolutionarily new genes in humans with disease phenotypes reveal functional enrichment patterns shaped by adaptive innovation and sexual selection.Semantic proximity Read ↗

Evidence for sex-specific genetic architectures across a spectrum of human complex traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.