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Article

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

JAMA neurology - 1 Jun 2016

Geha Paul, Yang Yang, Estacion Mark, Schulman Betsy R, Tokuno Hajime, Apkarian A Vania, Dib-Hajj Sulayman D, Waxman Stephen G

Abstract excerpt

IMPORTANCE: There is a need for more effective pharmacotherapy for chronic pain, including pain in inherited erythromelalgia (IEM) in which gain-of-function mutations of sodium channel NaV1.7 make dorsal root ganglion (DRG) neurons hyperexcitable. OBJECTIVE: To determine whether pain in IEM can be attenuated via pharmacotherapy guided by genomic analysis and functional profiling. DESIGN, SETTING, AND...

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Identifiers

PMID: 27088781
DOI: 10.1001/jamaneurol.2016.0389

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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