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Endoplasmic reticulum stress and intestinal inflammation

28 Oct 2009

Abstract excerpt

The intestinal epithelial cell (IEC) is increasingly recognized to play a prominent role as an important intermediary between the commensal microbiota and the intestinal immune system. Moreover, it is now recognized that intestinal inflammation in inflammatory bowel disease (IBD) may arise primarily from IEC dysfunction due to unresolved endoplasmic reticulum (ER) stress as a consequence of genetic disruption of...

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PMID: 19865077
DOI: 10.1038/mi.2009.122

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